Otogenic Aspergillus Brain Abscess in an SLE Teen — Successful Combined Surgical-Antifungal Management

Key finding

> Neuroaspergillosis carries near-universal mortality in immunocompromised hosts. Survival here required (a) recognition of chronic otitis media as a fungal portal in an SLE patient, (b) escalation from aspiration to radical excision when initial antifungal-plus-aspiration failed, and (c) prolonged step-down to oral posaconazole. Two months out the patient remained well — a meaningful proof-of-concept for aggressive combined therapy.

Framework connections: The Immune Priming, The Signal Fire (IL-6)

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