GCA in AION — North-Central Indian Case Series (SGPGI Lucknow 2026)

Key finding

> Standard medicine assumes GCA is rare in Indian patients and looks for the "classical" triad (headache + jaw claudication + PMR). This series shows that **a significant minority (13.3%) of AION cases in North-Central Indian elderly are GCA**, and that 3 in 4 of those cases will be missed if clinicians require systemic features before testing ESR/CRP and proceeding to temporal artery biopsy. GCA has been historically considered a disease of Northern European geriatrics, with reports from the Indian subcontinent characterised as "rare." This series suggests the rarity may be a detection artifact driven by absence of routine ESR/CRP-based screening in Indian AION workups — not absence of disease. ---

Framework connections: The Signal Fire (IL-6), The Immune Priming, The Missing Mechanics (EPCs)

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